Ontology highlight
ABSTRACT:
SUBMITTER: Avery J
PROVIDER: S-EPMC2913227 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Avery Joan J Etzion Sharon S DeBosch Brian J BJ Jin Xiaohua X Lupu Traian S TS Beitinjaneh Bassel B Grand Jacob J Kovacs Attila A Sambandam Nandakumar N Muslin Anthony J AJ
Circulation research 20100401 9
<h4>Rationale</h4>Tribbles (TRB)3 is an intracellular pseudokinase that modulates the activity of several signal transduction cascades. TRB3 has been reported to inhibit the activity of Akt protein kinases. TRB3 gene expression is highly regulated in many cell types, and amino acid starvation, hypoxia, or endoplasmic reticulum (ER) stress promotes TRB3 expression in noncardiac cells.<h4>Objective</h4>The objective of this work was to examine TRB3 expression and function in cultured cardiac myocy ...[more]