Ontology highlight
ABSTRACT:
SUBMITTER: Theveneau E
PROVIDER: S-EPMC2913244 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Theveneau Eric E Marchant Lorena L Kuriyama Sei S Gull Mazhar M Moepps Barbara B Parsons Maddy M Mayor Roberto R
Developmental cell 20100701 1
Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell p ...[more]