Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.

ABSTRACT:

Background

Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens.

Methods

We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a total of 17 300 subjects from five LC studies and four upper aerodigestive tract (UADT) cancer studies.

Results

Subjects with one minor allele smoked on average 0.3 cigarettes per day (CPD) more, whereas subjects with the homozygous minor AA genotype smoked on average 1.2 CPD more than subjects with a GG genotype (P < 0.001). The variant was associated with heavy s

SUBMITTER: Lips EH 

PROVIDER: S-EPMC2913450 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature