Ontology highlight
ABSTRACT:
SUBMITTER: Mary C
PROVIDER: S-EPMC2913627 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Mary C C Faraut F F Deniau M M Dereure J J Aoun K K Ranque S S Piarroux R R
International journal of microbiology 20100712
Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification. Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involved in trypanothione pathway, particularly gamma glutamyl cysteine synthase, and others involved in folates metabolism, such as dihydrofolate reductase and pterine reductase. The aim of this study was ...[more]