Ontology highlight
ABSTRACT:
SUBMITTER: Buckner FS
PROVIDER: S-EPMC2913713 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
Buckner F S FS Yokoyama K K Nguyen L L Grewal A A Erdjument-Bromage H H Tempst P P Strickland C L CL Xiao L L Van Voorhis W C WC Gelb M H MH
The Journal of biological chemistry 20000701 29
Protein prenylation occurs in the protozoan that causes African sleeping sickness (Trypanosoma brucei), and the protein farnesyltransferase appears to be a good target for developing drugs. We have cloned the alpha- and beta-subunits of T. brucei protein farnesyltransferase (TB-PFT) using nucleic acid probes designed from partial amino acid sequences obtained from the enzyme purified from insect stage parasites. TB-PFT is expressed in both bloodstream and insect stage parasites. Enzymatically ac ...[more]