Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC2914056 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks.
Chen Lina L Wang Hong H Zhang Liangcai L Li Wan W Wang Qian Q Shang Yukui Y He Yuehan Y He Weiming W Li Xu X Tai Jingxie J Li Xia X
BMC bioinformatics 20100722
<h4>Background</h4>Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological functions in their network neighbouring regions.<h4>Results</h4>Here, we weighted edges of a human protein interaction network and a transcriptional regulatory network to construct an integrated network, and introduce a probabilistic model and a bipartite graph framework to exploit human co-regulated modules and un ...[more]
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