Ontology highlight
ABSTRACT:
SUBMITTER: Kirkpatrick AS
PROVIDER: S-EPMC2914181 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Kirkpatrick Andrew S AS Yokoyama Takeshi T Choi Kyoung-Jae KJ Yeo Hye-Jeong HJ
Biochemical and biophysical research communications 20090301 2
Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The beta-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the c ...[more]