Ontology highlight
ABSTRACT:
SUBMITTER: Sastri J
PROVIDER: S-EPMC2914212 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sastri Jaya J O'Connor Christopher C Danielson Cindy M CM McRaven Michael M Perez Patricio P Diaz-Griffero Felipe F Campbell Edward M EM
Virology 20100714 1
The intracellular restriction factor TRIM5alpha, inhibits infection by numerous retroviruses in a species-specific manner. The best characterized example of this restriction is the TRIM5alpha protein from rhesus macaques (rhTRIM5alpha), which potently inhibits HIV-1 infection. TRIM5alpha localizes to cytoplasmic assemblies of protein referred to as cytoplasmic bodies, though the role that these bodies play in retroviral restriction is unclear. We employed a series of truncation mutants to identi ...[more]