Ontology highlight
ABSTRACT:
SUBMITTER: Moses SA
PROVIDER: S-EPMC2914301 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Moses Sylvestor A SA Ali M Ahad MA Zuohe Song S Du-Cuny Lei L Zhou Li Li LL Lemos Robert R Ihle Nathan N Skillman A Geoffrey AG Zhang Shuxing S Mash Eugene A EA Powis Garth G Meuillet Emmanuelle J EJ
Cancer research 20090602 12
The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating survival and antiapoptotic pathways within cancer cells. Several studies have shown that this pathway is constitutively activated in many different cancer types. The goal of this study was to discover novel compounds that bind to the pleckstrin homology (PH) domain of AKT, thereby inhibiting AKT activation. Using proprietary docking software, 22 potential PH domain inhibitors were identified. Surface plas ...[more]