Ontology highlight
ABSTRACT:
SUBMITTER: Nicoli S
PROVIDER: S-EPMC2914488 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Nicoli Stefania S Standley Clive C Walker Paul P Hurlstone Adam A Fogarty Kevin E KE Lawson Nathan D ND
Nature 20100404 7292
Within the circulatory system, blood flow regulates vascular remodelling, stimulates blood stem cell formation, and has a role in the pathology of vascular disease. During vertebrate embryogenesis, vascular patterning is initially guided by conserved genetic pathways that act before circulation. Subsequently, endothelial cells must incorporate the mechanosensory stimulus of blood flow with these early signals to shape the embryonic vascular system. However, few details are known about how these ...[more]