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The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract.

ABSTRACT:

Purpose

This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.

Methods

Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.

Results

Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).

Conclusion

There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

SUBMITTER: Verpoest W 

PROVIDER: S-EPMC2914592 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract.

Verpoest Willem W   Seneca Sara S   De Rademaeker Marjan M   Sermon Karen K   De Rycke Martine M   De Vos Michel M   Haentjens Patrick P   Devroey Paul P   Liebaers Ingeborg I  

Journal of assisted reproduction and genetics 20100311 6

<h4>Purpose</h4>This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.<h4>Methods</h4>Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.<h4>Results</h4>Between 1995 and 2005, 205 cycles of ICSI and PGD were carried ou  ...[more]

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