Ontology highlight
ABSTRACT:
SUBMITTER: Mazin PV
PROVIDER: S-EPMC2914642 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Algorithms for molecular biology : AMB 20100715
<h4>Background</h4>Recent progress in sequencing and 3 D structure determination techniques stimulated development of approaches aimed at more precise annotation of proteins, that is, prediction of exact specificity to a ligand or, more broadly, to a binding partner of any kind.<h4>Results</h4>We present a method, SDPclust, for identification of protein functional subfamilies coupled with prediction of specificity-determining positions (SDPs). SDPclust predicts specificity in a phylogeny-indepen ...[more]