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Tuning hydrogel properties and function using substituent effects.


ABSTRACT: The physical properties and function of hydrogels are shown to depend on the substituents present in three novel 1,3,5-tri-azaadamantane (TAA) cross-linkers. Gel stiffness and degradation rate at varied pHs could be predictably tuned with the cross-linker substituents used to form the gel. Subsequently, protein release from the hydrogel were controlled with chemical structure of the cross-linker.

SUBMITTER: Kohman RE 

PROVIDER: S-EPMC2915463 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Tuning hydrogel properties and function using substituent effects.

Kohman Richie E RE   Cha Chaenyung C   Zimmerman Steven C SC   Kong Hyunjoon H  

Soft matter 20100101


The physical properties and function of hydrogels are shown to depend on the substituents present in three novel 1,3,5-tri-azaadamantane (TAA) cross-linkers. Gel stiffness and degradation rate at varied pHs could be predictably tuned with the cross-linker substituents used to form the gel. Subsequently, protein release from the hydrogel were controlled with chemical structure of the cross-linker. ...[more]

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