DNA mismatch repair in eukaryotes and bacteria.
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ABSTRACT:
SUBMITTER: Fukui K
PROVIDER: S-EPMC2915661 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. T ...[more]
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