Ontology highlight
ABSTRACT:
SUBMITTER: Watashi K
PROVIDER: S-EPMC2915707 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100607 32
MicroRNAs (miRNAs) act in post-transcriptional gene silencing and are proposed to function in a wide spectrum of pathologies, including cancers and viral diseases. Currently, to our knowledge, no detailed mechanistic characterization of small molecules that interrupt miRNA pathways have been reported. In screening a small chemical library, we identified compounds that suppress RNA interference activity in cultured cells. Two compounds were characterized; one impaired Dicer activity while the oth ...[more]