Ontology highlight
ABSTRACT:
SUBMITTER: Fox AS
PROVIDER: S-EPMC2915894 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Fox Andrew S AS Shelton Steven E SE Oakes Terrence R TR Converse Alexander K AK Davidson Richard J RJ Kalin Ned H NH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 20
In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion on a complex neural circuit extends beyond the lesion location. Complementary functional imaging method ...[more]