Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits.
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ABSTRACT:
SUBMITTER: Buckholtz JW
PROVIDER: S-EPMC2916168 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits.
Buckholtz Joshua W JW Treadway Michael T MT Cowan Ronald L RL Woodward Neil D ND Benning Stephen D SD Li Rui R Ansari M Sib MS Baldwin Ronald M RM Schwartzman Ashley N AN Shelby Evan S ES Smith Clarence E CE Cole David D Kessler Robert M RM Zald David H DH
Nature neuroscience 20100314 4
Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride positron emission tomography and blood oxygen level-dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiolog ...[more]
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