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Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics.


ABSTRACT: Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily.

SUBMITTER: Lang KS 

PROVIDER: S-EPMC2916469 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics.

Lang Kevin S KS   Anderson Janet M JM   Schwarz Stefan S   Williamson Lynn L   Handelsman Jo J   Singer Randall S RS  

Applied and environmental microbiology 20100611 15


Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily. ...[more]

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