Ontology highlight
ABSTRACT:
SUBMITTER: Kopec KO
PROVIDER: S-EPMC2916718 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Kopec Klaus O KO Alva Vikram V Lupas Andrei N AN
Bioinformatics (Oxford, England) 20100616 16
Mitochondria must uptake some phospholipids from the endoplasmic reticulum (ER) for the biogenesis of their membranes. They convert one of these lipids, phosphatidylserine, to phosphatidylethanolamine, which can be re-exported via the ER to all other cellular membranes. The mechanisms underlying these exchanges between ER and mitochondria are poorly understood. Recently, a complex termed ER-mitochondria encounter structure (ERMES) was shown to be necessary for phospholipid exchange in budding ye ...[more]