Ontology highlight
ABSTRACT:
SUBMITTER: Hollander JA
PROVIDER: S-EPMC2916751 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Hollander Jonathan A JA Im Heh-In HI Amelio Antonio L AL Kocerha Jannet J Bali Purva P Lu Qun Q Willoughby David D Wahlestedt Claes C Conkright Michael D MD Kenny Paul J PJ
Nature 20100701 7303
Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that microRNA-212 (miR-212) is upregulated in the dorsal striatum of rats with a history of extended access to cocaine. Striatal miR-212 decreases responsiveness to the motivational properties of cocaine by markedly amplifying the stimulatory effects of the drug on cAMP response element binding protein (CREB) signallin ...[more]