Biological and structural characterization of a host-adapting amino acid in influenza virus.
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ABSTRACT:
SUBMITTER: Yamada S
PROVIDER: S-EPMC2916879 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Biological and structural characterization of a host-adapting amino acid in influenza virus.
Yamada Shinya S Hatta Masato M Staker Bart L BL Watanabe Shinji S Imai Masaki M Shinya Kyoko K Sakai-Tagawa Yuko Y Ito Mutsumi M Ozawa Makoto M Watanabe Tokiko T Sakabe Saori S Li Chengjun C Kim Jin Hyun JH Myler Peter J PJ Phan Isabelle I Raymond Amy A Smith Eric E Stacy Robin R Nidom Chairul A CA Lank Simon M SM Wiseman Roger W RW Bimber Benjamin N BN O'Connor David H DH Neumann Gabriele G Stewart Lance J LJ Kawaoka Yoshihiro Y
PLoS pathogens 20100805 8
Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals. However, the recently emerged pandemic H1N1 viruses lack these amino acids. Here, we report that a basic amino acid at position 591 of PB2 can compensate for the lack of lysine at position 627 and confers efficient viral replication to pandemic H1N1 viruses in mammals. Moreover, a basic amino acid at posit ...[more]
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