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The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis.


ABSTRACT: In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development.

SUBMITTER: Heimel K 

PROVIDER: S-EPMC2916880 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis.

Heimel Kai K   Scherer Mario M   Vranes Miroslav M   Wahl Ramon R   Pothiratana Chetsada C   Schuler David D   Vincon Volker V   Finkernagel Florian F   Flor-Parra Ignacio I   Kämper Jörg J  

PLoS pathogens 20100805 8


In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these gen  ...[more]

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