Ontology highlight
ABSTRACT:
SUBMITTER: Shi X
PROVIDER: S-EPMC2917224 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Shi Xiangyang X Wang Su He SH Van Antwerp Mary E ME Chen Xisui X Baker James R JR
The Analyst 20090417 7
We develop a facile approach to fabricating multifunctional dendrimer-stabilized gold nanoparticles (Au DSNPs) for cancer cell targeting and imaging. In this work, amine-terminated generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers pre-functionalized with folic acid (FA) and fluorescein isothiocyanate (FI) are complexed with Au(III) ions, followed by acetylation of the amine groups on the dendrimer surfaces. This one-step process leads to the spontaneous formation of 6 nm-sized Au nanoparticl ...[more]