Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC2917475 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chen Wenxing W Luo Yan Y Liu Lei L Zhou Hongyu H Xu Baoshan B Han Xiuzhen X Shen Tao T Liu Zhijun Z Lu Yin Y Huang Shile S
Cancer prevention research (Philadelphia, Pa.) 20100713 8
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target o ...[more]