Ontology highlight
ABSTRACT:
SUBMITTER: Chakravarty P
PROVIDER: S-EPMC2917490 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chakravarty Prerona P Qian Wei W El-Sayed Mostafa A MA Prausnitz Mark R MR
Nature nanotechnology 20100718 8
A major barrier to drug and gene delivery is crossing the cell's plasma membrane. Physical forces applied to cells via electroporation, ultrasound and laser irradiation generate nanoscale holes in the plasma membrane for direct delivery of drugs into the cytoplasm. Inspired by previous work showing that laser excitation of carbon nanoparticles can drive the carbon-steam reaction to generate highly controlled shock waves, we show that carbon black nanoparticles activated by femtosecond laser puls ...[more]