Ontology highlight
ABSTRACT:
SUBMITTER: Akimova T
PROVIDER: S-EPMC2917523 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Akimova Tatiana T Ge Guanghui G Golovina Tatiana T Mikheeva Tatiana T Wang Liqing L Riley James L JL Hancock Wayne W WW
Clinical immunology (Orlando, Fla.) 20100515 3
Histone/protein deacetylases (HDACs) decrease histone and protein acetylation, typically leading to suppression of gene transcription and modulation of various protein functions. We found significant differences in expression of HDAC before and after stimulation of human T regulatory (Treg) and T effector cells, suggesting the potential for future selective targeting of Tregs with HDAC inhibitors (HDACi). Use of various HDACi small molecules enhanced, by up to 4.5-fold (average 2-fold), the supp ...[more]