Ontology highlight
ABSTRACT:
SUBMITTER: Choi J
PROVIDER: S-EPMC2917600 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Choi Jungyuen J Zhai Dayong D Zhou Xin X Satterthwait Arnold A Reed John C JC Marassi Francesca M FM
Chemical biology & drug design 20071010 5
Humanin is a short endogenous peptide, which can provide protection from cell death through its association with various receptors, including the pro-apoptotic Bcl-2 family proteins Bid, Bim, and Bax. By using NMR chemical shift mapping experiments, we demonstrate that the interaction between Humanin-derived peptides and Bid is specific, and we localize the binding site to a region on the surface of Bid, which includes residues from the conserved helical BH3 domain of the protein. The BH3 domain ...[more]