Ontology highlight
ABSTRACT:
SUBMITTER: Frearson JA
PROVIDER: S-EPMC2917743 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Frearson Julie A JA Brand Stephen S McElroy Stuart P SP Cleghorn Laura A T LA Smid Ondrej O Stojanovski Laste L Price Helen P HP Guther M Lucia S ML Torrie Leah S LS Robinson David A DA Hallyburton Irene I Mpamhanga Chidochangu P CP Brannigan James A JA Wilkinson Anthony J AJ Hodgkinson Michael M Hui Raymond R Qiu Wei W Raimi Olawale G OG van Aalten Daan M F DM Brenk Ruth R Gilbert Ian H IH Read Kevin D KD Fairlamb Alan H AH Ferguson Michael A J MA Smith Deborah F DF Wyatt Paul G PG
Nature 20100401 7289
African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma brucei spp., is responsible for approximately 30,000 deaths each year. Available treatments for this disease are poor, with unacceptable efficacy and safety profiles, particularly in the late stage of the disease when the parasite has infected the central nervous system. Here we report the validation of a molecular target and the discovery of associated lead compounds with the potential to address this lack of suit ...[more]