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Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.

ABSTRACT: Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described, using the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.

SUBMITTER: Liu Z

PROVIDER: S-EPMC2917892 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.

Liu Zhang Z Nefzi Adel A

Journal of combinatorial chemistry 20100701 4

Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described, using the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines. ...[more]

PMID: 20527770

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