Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.

ABSTRACT: Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described, using the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC2917892 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature