Ontology highlight
ABSTRACT:
SUBMITTER: Carnevalli LS
PROVIDER: S-EPMC2918254 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Developmental cell 20100501 5
Earlier, we reported that S6K1(-/-) mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant to high fat diet (HFD)-induced obesity. Here we report that adipocytes of S6K1(-/-) mice on a HFD have the capacity to increase in size to a degree comparable to that of wild-type (WT) mice, but not in number, indicating an unexpected lesion in adipogenesis. Tracing this lesion revealed that S6K1 is dispensable for terminal adipocyte dif ...[more]