Ontology highlight
ABSTRACT:
SUBMITTER: Koinuma D
PROVIDER: S-EPMC291827 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Koinuma Daizo D Shinozaki Masahiko M Komuro Akiyoshi A Goto Kouichiro K Saitoh Masao M Hanyu Aki A Ebina Masahito M Nukiwa Toshihiro T Miyazawa Keiji K Imamura Takeshi T Miyazono Kohei K
The EMBO journal 20031201 24
Arkadia was originally identified as a protein that enhances signalling activity of Nodal and induces mammalian nodes during early embryogenesis; however, the mechanisms by which Arkadia affects transforming growth factor-beta (TGF-beta) superfamily signalling have not been determined. Here we show that Arkadia is widely expressed in mammalian tissues, and that it enhances both TGF-beta and bone morphogenetic protein (BMP) signalling. Arkadia physically interacts with inhibitory Smad, Smad7, and ...[more]