Ontology highlight
ABSTRACT:
SUBMITTER: Huttunen HJ
PROVIDER: S-EPMC2918281 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Huttunen Henri J HJ Havas Daniel D Peach Camilla C Barren Cory C Duller Stephan S Xia Weiming W Frosch Matthew P MP Hutter-Paier Birgit B Windisch Manfred M Kovacs Dora M DM
Journal of neuropathology and experimental neurology 20100801 8
Cerebral accumulation of amyloid-beta (Abeta) is characteristic of Alzheimer disease and of amyloid precursor protein (APP) transgenic mice. Here, we assessed the efficacy of CI-1011, an inhibitor of acyl-coenzyme A:cholesterol acyltransferase, which is suitable for clinical use, in reducing amyloid pathology in both young (6.5 months old) and aged (16 months old) human APP transgenic mice. Treatment of young animals with CI-1011 decreased amyloid plaque load in the cortex and hippocampus and re ...[more]