Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
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SUBMITTER: Ho PA
PROVIDER: S-EPMC2918327 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
Ho Phoenix A PA Zeng Rong R Alonzo Todd A TA Gerbing Robert B RB Miller Kristen L KL Pollard Jessica A JA Stirewalt Derek L DL Heerema Nyla A NA Raimondi Susana C SC Hirsch Betsy B Franklin Janet L JL Lange Beverly B Meshinchi Soheil S
Blood 20100422 5
Recent studies of WT1 mutations in acute myeloid leukemia (AML) mostly report an association with unfavorable clinical outcome. We screened 842 patients treated on 3 consecutive pediatric AML trials for WT1 zinc-finger mutations. Eighty-five mutations were detected in 70 of 842 patients (8.3%). Mutations occurred predominantly in exon 7 (n = 74) but were also found in exons 8 (n = 5) and 9 (n = 6). Normal karyotype was observed in 35.3% of WT1(mut) patients, whereas 27.5% WT1(mut) patients harbo ...[more]
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2009-06-25 | E-GEOD-11877 | biostudies-arrayexpress
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