Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC2918394 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100701 13
The design, synthesis, X-ray crystal structure, molecular modeling, and biological evaluation of a series of new generation SARS-CoV PLpro inhibitors are described. A new lead compound 3 (6577871) was identified via high-throughput screening of a diverse chemical library. Subsequently, we carried out lead optimization and structure-activity studies to provide a series of improved inhibitors that show potent PLpro inhibition and antiviral activity against SARS-CoV infected Vero E6 cells. Interest ...[more]