Ontology highlight
ABSTRACT:
SUBMITTER: Ishitani T
PROVIDER: S-EPMC291846 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Ishitani Tohru T Takaesu Giichi G Ninomiya-Tsuji Jun J Shibuya Hiroshi H Gaynor Richard B RB Matsumoto Kunihiro K
The EMBO journal 20031201 23
The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-kappaB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL-1- and TNF-induced activation of the NF-kappaB pathway. TAB2, a TAK1-binding protein, is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. However, IL-1-induced activation of NF-kappaB is not impaired in TAB2-deficient embryonic fibroblasts. Here we report the identificat ...[more]