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MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.

ABSTRACT: In the developing CNS, neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that microRNAs (miRNAs) play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1(Cre)-mediated Dicer conditional knock-out mice disrupted both oligodendrogenesis and astrogliogenesis in the ventral neuroepithelial cells. By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.

SUBMITTER: Zheng K

PROVIDER: S-EPMC2918643 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.

Zheng Kang K Li Hong H Zhu Ying Y Zhu Qiang Q Qiu Mengsheng M

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100601 24

In the developing CNS, neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that microRNAs (miRNAs) play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1(Cre)-mediated Dicer conditional knock-out mice disrupted both oligodendrogenesis and astrogliogen ...[more]

PMID: 20554876

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