Ontology highlight
ABSTRACT:
SUBMITTER: Long KS
PROVIDER: S-EPMC291879 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Long Katherine S KS Porse Bo T BT
Nucleic acids research 20031201 24
The antibiotic chloramphenicol produces modifications in 23S rRNA when bound to ribosomes from the bacterium Escherichia coli and the archaeon Halobacterium halobium and irradiated with 365 nm light. The modifications map to nucleotides m(5)U747 and C2611/C2612, in domains II and V, respectively, of E.coli 23S rRNA and G2084 (2058 in E.coli numbering) in domain V of H.halobium 23S rRNA. The modification sites overlap with a portion of the macrolide binding site and cluster at the entrance to the ...[more]