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ABSTRACT:
SUBMITTER: Holscher T
PROVIDER: S-EPMC2918973 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Hölscher Tina T Breuer Uta U Adrian Lorenz L Harms Hauke H Maskow Thomas T
Applied and environmental microbiology 20100625 16
In this study, a methylotrophic bacterium, Methylobacterium rhodesianum MB 126, was used for the production of the chiral compound (R)-3-hydroxybutyrate (R-3HB) from methanol. R-3HB is formed during intracellular degradation of the storage polymer (R)-3-polyhydroxybutyrate (PHB). Since the monomer R-3HB does not accumulate under natural conditions, M. rhodesianum was genetically modified. The gene (hbd) encoding the R-3HB-degrading enzyme, R-3HB dehydrogenase, was inactivated in M. rhodesianum. ...[more]