Ontology highlight
ABSTRACT:
SUBMITTER: Kalea AZ
PROVIDER: S-EPMC2919303 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Kalea Anastasia Z AZ See Fiona F Harja Evis E Arriero Maria M Schmidt Ann Marie AM Hudson Barry I BI
Cancer research 20100622 13
Receptor for advanced glycation end products (RAGE) and its ligands are overexpressed in multiple cancers. RAGE has been implicated in tumorigenesis and metastasis, but little is known of the mechanisms involved. In this study, we define a specific functional role for an alternate splice variant termed RAGE splice variant 1 (RAGEv1), which encodes a soluble endogenous form of the receptor that inhibits tumorigenesis. RAGEv1 was downregulated in lung, prostate, and brain tumors relative to contro ...[more]