Ontology highlight
ABSTRACT:
SUBMITTER: Kalet BT
PROVIDER: S-EPMC2919335 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Kalet Brian T BT McBryde Meagan B MB Espinosa Joaquin M JM Koch Tad H TH
Journal of medicinal chemistry 20070816 18
The mechanism of doxorubicin is compared with that of doxazolidine, a doxorubicin-formaldehyde conjugate. The IC(50) for growth inhibition of 67 human cancer cell lines, but not cardiomyocytes, is 32-fold lower with doxazolidine than with doxorubicin. Growth inhibition by doxazolidine correlates better with growth inhibition by DNA cross-linking agents than with growth inhibition by doxorubicin. Doxorubicin induces G2/M arrest in HCT-116 colon cancer cells and HL-60 leukemia cells through a well ...[more]