Ontology highlight
ABSTRACT:
SUBMITTER: Kulaeva OI
PROVIDER: S-EPMC2919570 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20091122 12
Transcription of eukaryotic genes by RNA polymerase II (Pol II) is typically accompanied by nucleosome survival and minimal exchange of histones H3 and H4. The mechanism of nucleosome survival and recovery of chromatin structure remains obscure. Here we show how transcription through chromatin by Pol II is uniquely coupled with nucleosome survival. Structural modeling and functional analysis of the intermediates of transcription through a nucleosome indicated that when Pol II approaches an area ...[more]