Ontology highlight
ABSTRACT:
SUBMITTER: Ruprich-Robert G
PROVIDER: S-EPMC2919709 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ruprich-Robert Gwenaël G Thuriaux Pierre P
Nucleic acids research 20100331 14
DNA transcription depends on multimeric RNA polymerases that are exceptionally conserved in all cellular organisms, with an active site region of >500 amino acids mainly harboured by their Rpb1 and Rpb2 subunits. Together with the distantly related eukaryotic RNA-dependent polymerases involved in gene silencing, they form a monophyletic family of ribonucleotide polymerases with a similarly organized active site region based on two double-Psi barrels. Recent viral and phage genome sequencing have ...[more]