Ontology highlight
ABSTRACT:
SUBMITTER: Hirota S
PROVIDER: S-EPMC2919943 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Hirota Shun S Hattori Yoko Y Nagao Satoshi S Taketa Midori M Komori Hirofumi H Kamikubo Hironari H Wang Zhonghua Z Takahashi Isao I Negi Shigeru S Sugiura Yukio Y Kataoka Mikio M Higuchi Yoshiki Y
Proceedings of the National Academy of Sciences of the United States of America 20100706 29
Cytochrome c (cyt c) is a stable protein that functions in a monomeric state as an electron donor for cytochrome c oxidase. It is also released to the cytosol when permeabilization of the mitochondrial outer membrane occurs at the early stage of apoptosis. For nearly half a century, it has been known that cyt c forms polymers, but the polymerization mechanism remains unknown. We found that cyt c forms polymers by successive domain swapping, where the C-terminal helix is displaced from its origin ...[more]