Consistency of predictive signature genes and classifiers generated using different microarray platforms.
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ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC2920073 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Consistency of predictive signature genes and classifiers generated using different microarray platforms.
Fan X X Lobenhofer E K EK Chen M M Shi W W Huang J J Luo J J Zhang J J Walker S J SJ Chu T-M TM Li L L Wolfinger R R Bao W W Paules R S RS Bushel P R PR Li J J Shi T T Nikolskaya T T Nikolsky Y Y Hong H H Deng Y Y Cheng Y Y Fang H H Shi L L Tong W W
The pharmacogenomics journal 20100801 4
Microarray-based classifiers and associated signature genes generated from various platforms are abundantly reported in the literature; however, the utility of the classifiers and signature genes in cross-platform prediction applications remains largely uncertain. As part of the MicroArray Quality Control Phase II (MAQC-II) project, we show in this study 80-90% cross-platform prediction consistency using a large toxicogenomics data set by illustrating that: (1) the signature genes of a classifie ...[more]
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