Ontology highlight
ABSTRACT:
SUBMITTER: Shigetomi E
PROVIDER: S-EPMC2920135 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Shigetomi Eiji E Kracun Sebastian S Sofroniew Michael V MV Khakh Baljit S BS
Nature neuroscience 20100523 6
Calcium signaling is studied as a potential form of astrocyte excitability that may control astrocyte involvement in synaptic and cerebrovascular regulation. Fundamental questions remain unanswered about astrocyte calcium signaling, as current methods can not resolve calcium in small volume compartments, such as near the cell membrane and in distal cell processes. We modified the genetically encoded calcium sensor GCaMP2 with a membrane-tethering domain, Lck, increasing the level of Lck-GCaMP2 n ...[more]