Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.

ABSTRACT:

Objectives

Efavirenz is extensively metabolized by CYP2B6, and associations between CYP2B6 polymorphisms and plasma efavirenz exposure have been reported. The objective of this study was to investigate CYP2B6 haplotype structure and functional consequences in a Latin American population.

Patients and methods

Two hundred and nineteen patients were recruited at Fundación Arriarán, Chile, between September and December 2008. Plasma efavirenz concentrations were determined using liquid chromatography with mass spectrometry. Genotyping for 30 single nucleotide polymorphisms (SNPs) with a minor allele frequency of >0.05 in the HapMap CEU population at intervals of approximately 1 kb across the CYP2B6 locus was conducted using Sequenom iPLEX MALDI-TOF.

Results

Thirteen SNPs

SUBMITTER: Carr DF 

PROVIDER: S-EPMC2920179 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature