Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.
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ABSTRACT:
SUBMITTER: Chai S
PROVIDER: S-EPMC2920269 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
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Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.
Chai Stella S To Kenneth Kw KK Lin Ge G
Chinese medicine 20100725
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied f ...[more]
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