Ontology highlight
ABSTRACT:
SUBMITTER: Donner AJ
PROVIDER: S-EPMC2920286 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Donner Aaron J AJ Ebmeier Christopher C CC Taatjes Dylan J DJ Espinosa Joaquín M JM
Nature structural & molecular biology 20100124 2
The Mediator complex allows communication between transcription factors and RNA polymerase II (RNAPII). Cyclin-dependent kinase 8 (CDK8), the kinase found in some variants of Mediator, has been characterized mostly as a transcriptional repressor. Recently, CDK8 was demonstrated to be a potent oncoprotein. Here we show, using a human tumor cell line, that CDK8 is a positive regulator of genes within the serum response network, including several members of the activator protein 1 and early growth ...[more]