Ontology highlight
ABSTRACT:
SUBMITTER: Liu XS
PROVIDER: S-EPMC2920445 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Liu X Shawn XS Li Hongchang H Song Bing B Liu Xiaoqi X
EMBO reports 20100625 8
In response to G2 DNA damage, the p53 pathway is activated to lead to cell-cycle arrest, but how p53 is eliminated during the subsequent recovery process is poorly understood. It has been established that Polo-like kinase 1 (Plk1) controls G2 DNA-damage recovery. However, whether Plk1 activity contributes to p53 inactivation during this process is unknown. In this study, we show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery a ...[more]