Ontology highlight
ABSTRACT:
SUBMITTER: Sycuro LK
PROVIDER: S-EPMC2920535 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Sycuro Laura K LK Pincus Zachary Z Gutierrez Kimberley D KD Biboy Jacob J Stern Chelsea A CA Vollmer Waldemar W Salama Nina R NR
Cell 20100501 5
The mechanisms by which bacterial cells generate helical cell shape and its functional role are poorly understood. Helical shape of the human pathogen Helicobacter pylori may facilitate penetration of the thick gastric mucus where it replicates. We identified four genes required for helical shape: three LytM peptidoglycan endopeptidase homologs (csd1-3) and a ccmA homolog. Surrounding the cytoplasmic membrane of most bacteria, the peptidoglycan (murein) sacculus is a meshwork of glycan strands j ...[more]